Oral and Maxillofacial Pathology Review for NBDE Part 2- 1

Systemic Lupus Erythematosus

Clinical

–Autoimmune

–Young adult females

Butterfly rash of face

Sun exposure worsens it

–Systemic involvement complications

Heart – endocarditis

Kidney – renal glomeruli (glomerulonephritis)

Cavernous sinus thrombosis

Can arise from an infection – – a subcutaneous abscess of the upper lip or a intrabony abscess of an anterior maxillary tooth

–Valveless facial veins

Ludwig’s angina

Submandibular space infection

Most serious complication is edema of the glottis

Treacher Collins Syndrome

Has external ear changes

Scarlet fever

White coating of the tongue that sloughs off leaving a deep red surface with swollen hyperplastic fungiform papillae (“strawberry tongue”)

Fordyce granules

Ectopic sebaceous glands – yellow papules/plaques

Turner tooth

Due to local trauma or infection associated with the developing tooth bud

Intrinsic tooth stain

Tetracycline – deposition within the dentin

Recurrent Aphthous Stomatitis

#Clinical

–Moveable mucosa

#Ex. Uvula, labial mucosa

–Recurrent – NOT PRECEDED BY VESICLE

–Associated with certain HLA types

#NOT caused by a virus, bacteria, fungus

–Treatment

#Corticosteroids are often prescribed

–Herpetiform type

#Many small

–Minor and major types

#Very painful

#Size, depth, time to heal (minor 5-10 days)

#Minor – small, shallow ulcer with red halo

Benign Mucous Membrane Pemphigoid (cicatricial)

#Clinical

–Autoimmune

#Antibody reaction at the

epithelial-connective tissue

interface (BMZ)

#Subepithelial split

–Vesiculoerosive, ulcers

–> women – middle aged

–Skin and eye

–Oral

#Any site: gingiva, soft palate, etc.

#Ulcers, erosions following vesicles, bulla

#Histology

–Subepithelial separation at basement membrane zone

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